- Title
- Prevalence and clinical risk prediction of hypertriglyceridaemia in a community cohort
- Creator
- Tan, Hong L. E.; Hure, Alexis; Peel, Roseanne; Hancock, Stephen; Attia, John
- Relation
- Internal Medicine Journal Vol. 53, Issue 3, p. 363-372
- Publisher Link
- http://dx.doi.org/10.1111/imj.15626
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2023
- Description
- Background: Hypertriglyceridaemia (HTG; defined as ≥1.7 mmol/L) has a prevalence of 18–33% with significant inter-regional variation. Despite meta-analysis demonstrating its association with increased risk of cardiovascular disease, only 40% of HTG is identified in the community resulting in underutilisation of lipid-lowering therapy and specialist clinics. An increase in awareness of its clinical risk factors is needed to improve the identification and management of HTG to prevent cardiovascular risk. Aims: To evaluate the prevalence, distribution and clinical predictors of HTG ≥1.7 mmol/L in a representative community group. Methods: Data were obtained from the Hunter Community Study (HCS), a longitudinal cohort of community-dwelling men and women aged 55−85 years residing in Newcastle, New South Wales. Fasting triglycerides were identified based on the availability of fasting blood glucose level and categorised according to normal (<1.7 mmol/L), mild (1.7 to <2.3 mmol/L) and moderate–severe HTG (≥2.3 mmol/L). Clinical predictors of HTG were assessed using linear and logistic regression models. Results: Of 2536 triglyceride levels, 2216 (87%) were in a fasting state and included in the study. Three hundred and two (13.6%) participants had mild HTG and 221 (10.0%) participants had moderate–severe HTG. Significant clinical predictors of HTG included male gender, increasing body mass index, current smoking, decreasing daily step counts, increasing fasting glucose and higher thyroid-stimulating hormone. Alcohol intake and blood pressure were not significant in either adjusted regression model. Conclusions: HTG ≥1.7 mmol/L is common, affecting 24% of the HCS. Clinical predictors identify modifiable risk factors for cardiovascular risk management. Clinician education to promote awareness is required to improve patient outcomes.
- Subject
- hypertriglyceridaemia; triglyceride; hyperlipidaemia; cross-sectional study; prevalence; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1478360
- Identifier
- uon:50159
- Identifier
- ISSN:1444-0903
- Language
- eng
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